Endocrine Abstracts

The initial therapy for endogenous hypercortisolism (EH) or Cushing’s syndrome (CS) is almost always surgery. However, persistence or recurrence of EH is common and medical therapy may be needed to control the clinical and metabolic derangements associated with EH. Pituitary directed therapies include: Cabergoline, simple and well tolerated, cortisol (F) is normalized in 25-40% of patients but the effect is usually not enduring and Pasireotide, a somatostatin analog, redu...

Having been diagnosed with congenital adrenal hyperplasia at the age of 5. I have been lucky enough to turn out as an adult with minimal impact from the condition, and lead a broadly normal life. This brief talk intends to provide a brief diagnostic background for my case, but mainly to focus on the lasting benefits that medical professionals can provide to a patient.When dealing with children, the importance of providing factual education to the parents...

In this presentation, the main techniques for genital gender reassignment surgery, both male to female and female to male will be described. A brief outline of other surgery in both groups will also be presented....

Our understanding of the genetic abnormalities associated with thyroid cancers has grown significantly over the past decade. Thus, papillary thyroid cancers (PTC) have non-overlapping activating mutations genes encoding the growth factor receptors RET or NTRK, the three isoforms of RAS, or of BRAF, which altogether are found in ~70% of cases. In addition, mutations of effectors in the phosphoinositol-3-kinase (PI3K) pathway are present at various stages of the disease, but in ...

James A Fagin, Memorial Sloan-Kettering Cancer Center, New York, USA. AbstractJames A. Fagin is Chief of the Endocrine Service and a Member of the Human Oncology and Pathogenesis Program at Memorial Sloan-Kettering Cancer Center in New York, and a Professor of Medicine at Weill Medical College of Cornell University. He was formerly the James Heady Professor of Medicine and Director of the Division of Endocrinology and...

A 31 year-old lady presented to clinic with an acute, three-week history of rapidly worsening polyuria and polydipsia. She described an eighteen month history of dysmenorrhoea with no galactorrhoea and reported no change in her vision. Her past medical history included alopecia areata one year previously from which she made a full recovery. Clinical examination was normal including full visual fields to red-pin confrontation. Biochemistry identified serum sodium of 141 mmol/l,...

Introduction: Psychogenic polydipsia is a relatively uncommon condition characterized by overconsumption of water. It is known to be prevalent amongst psychiatric patients, but less common in the general population.Case report: A previously well 18-month-old girl presented to the emergency department in status epilepticus. There was no history of fever, recent weight loss, infection, trauma or any systemic medications. Post event questioning established ...

Stress hyperglycaemia is a widely recognised feature of critical illness. Spontaneous hypoglycaemia, by contrast, is an underappreciated but serious complication. Here I present three cases encountered over 12 months in a single teaching hospital.Case 1: 59 year old female. Admitted with fever and leg pain. Cellulitis diagnosed and antibiotics commenced. Hours later, she became unresponsive and shocked, with evident necrotisi...

Stress hyperglycaemia is a widely recognised feature of critical illness. Spontaneous hypoglycaemia, by contrast, is an underappreciated but serious complication. Here I present three cases encountered over 12 months in a single teaching hospital.Case 1: 59 year old female. Admitted with fever and leg pain. Cellulitis diagnosed and antibiotics commenced. Hours later, she became unresponsive and shocked, with evident necrotisi...

Neuroendocrine tumours (NETs) are distinctive tumours which arise from cells which have neural and hormonal origins. Gastroenteropancreatic tumours (GEP) are the most common clinically encountered NETs. Imaging has a lead role in the evaluation of these tumours – detection, staging and follow-up. It is also known that PET–CT with 18F-FDG has a limited value in well-differentiated NETs. This study was performed to evaluate the clinical value of 18</sup...